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Review
. 2003 Jun;36(3):165-75.
doi: 10.1046/j.1365-2184.2003.00267.x.

Cell cycle and apoptosis

Katrien Vermeulen  1 , Zwi N Berneman, Dirk R Van Bockstaele
Affiliations
Review

Cell cycle and apoptosis

Katrien Vermeulen et al. Cell Prolif. 2003 Jun.

Abstract

Apoptosis and proliferation are intimately coupled. Some cell cycle regulators can influence both cell division and programmed cell death. The linkage of cell cycle and apoptosis has been recognized for c-Myc, p53, pRb, Ras, PKA, PKC, Bcl-2, NF-kappa B, CDK, cyclins and CKI. This review summarizes the different functions of the proteins presently known to control both apoptosis and cell cycle progression. These proteins can influence apoptosis or proliferation but different variables, including cell type, cellular environment and genetic background, make it difficult to predict the outcome of cell proliferation, cell cycle arrest or cell death. These important decisions of cell proliferation or cell death are likely to be controlled by more than one signal and are necessary to ensure a proper cellular response.

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Figures

Figure 1
Figure 1
The role of c‐Myc in cell cycle and apoptosis.
Figure 2
Figure 2
The role of Ras in cell cycle and apoptosis.
See this image and copyright information in PMC

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