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Review
. 1992 Sep;13(9):362-7.
doi: 10.1016/0167-5699(92)90173-5.

Group A streptococcal M proteins: virulence factors and protective antigens

J H Robinson  1 , M A Kehoe
Affiliations
Review

Group A streptococcal M proteins: virulence factors and protective antigens

J H Robinson et al. Immunol Today. 1992 Sep.

Abstract

Rebecca Lancefield described group A streptococcal M proteins over 50 years ago, and they have remained at the forefront of investigations into streptococcal pathogenicity to the present day. As described in this review, they form cell surface fibrils with several functions, ranging from resisting phagocytosis and inducing host-crossreactive antibodies, to presenting the host immune system with an accessible protective antigen.

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