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. 2003 Jun 26;5(13):2255-7.
doi: 10.1021/ol034564u.

Massadine, a novel geranylgeranyltransferase type I inhibitor from the marine sponge Stylissa aff. massa

Shinichi Nishimura  1 , Shigeki Matsunaga, Mitsuyoshi Shibazaki, Kenichi Suzuki, Kazuo Furihata, Rob W M van Soest, Nobuhiro Fusetani
Affiliations

Massadine, a novel geranylgeranyltransferase type I inhibitor from the marine sponge Stylissa aff. massa

Shinichi Nishimura et al. Org Lett. .

Abstract

Massadine, a highly oxygenated alkaloid, was isolated from the marine sponge Stylissa aff. massa as an inhibitor of geranylgeranyltransferase type I (GGTase I). The structure of massadine has been deduced from spectral data. Massidine inhibited GGTase I from Candida albicans with an IC(50) value of 3.9 microM. [structure: see text]

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