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. 2003 Jun 26;5(13):2311-4.
doi: 10.1021/ol034659w.

Efficient nickel-mediated intramolecular amination of aryl chlorides

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Efficient nickel-mediated intramolecular amination of aryl chlorides

Rafik Omar-Amrani et al. Org Lett. .

Abstract

The use of an in situ generated Ni(0) catalyst associated with 2,2'-bipyridine or N,N'-bis(2,6-diisopropylphenyl)dihydroimidazol-2-ylidene (SIPr) as a ligand and NaO-t-Bu as the base for the intramolecular coupling of aryl chlorides with amines is described. The procedure has been applied to the formation of five-, six-, and seven-membered rings. [reaction: see text]

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