Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2003 Jun 26;5(13):2311-4.
doi: 10.1021/ol034659w.

Efficient nickel-mediated intramolecular amination of aryl chlorides

Rafik Omar-Amrani  1 , Antoine Thomas, Eric Brenner, Raphaël Schneider, Yves Fort
Affiliations

Efficient nickel-mediated intramolecular amination of aryl chlorides

Rafik Omar-Amrani et al. Org Lett. .

Abstract

The use of an in situ generated Ni(0) catalyst associated with 2,2'-bipyridine or N,N'-bis(2,6-diisopropylphenyl)dihydroimidazol-2-ylidene (SIPr) as a ligand and NaO-t-Bu as the base for the intramolecular coupling of aryl chlorides with amines is described. The procedure has been applied to the formation of five-, six-, and seven-membered rings. [reaction: see text]

PubMed Disclaimer

LinkOut - more resources