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. 2003 Apr;56(4):358-63.
doi: 10.7164/antibiotics.56.358.

YM-254890, a novel platelet aggregation inhibitor produced by Chromobacterium sp. QS3666

Masatoshi Taniguchi  1 , Koji Nagai, Nakako Arao, Tomihisa Kawasaki, Tetsu Saito, Yumiko Moritani, Jun Takasaki, Kazumi Hayashi, Shigeo Fujita, Ken-ichi Suzuki, Shin-ichi Tsukamoto
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Free article

YM-254890, a novel platelet aggregation inhibitor produced by Chromobacterium sp. QS3666

Masatoshi Taniguchi et al. J Antibiot (Tokyo). 2003 Apr.
Free article

Abstract

A novel platelet aggregation inhibitor, YM-254890, was isolated from the culture broth of strain QS3666. This strain was isolated from a soil sample collected at Okutama, Tokyo, Japan, and was identified as Chromobacterium sp. by morphological and physiological criteria. YM-254890 was purified from the culture supernatant by solvent extraction, ODS and silica gel flash chromatography, followed by preparative HPLC. YM-254890 inhibited ADP-induced platelet aggregation in human platelet-rich plasma with an IC50 value below 0.6 microM by blocking the P2Y1 receptor-signal transduction pathway.

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