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Comment
. 2003 Jun;18(6):721-2.
doi: 10.1016/s1074-7613(03)00143-2.

The activation of lymphocytes is in their CARMA

Abul K Abbas  1 , Ranjan Sen
Affiliations
Free article
Comment

The activation of lymphocytes is in their CARMA

Abul K Abbas et al. Immunity. 2003 Jun.
Free article

Abstract

Lymphocyte activation via antigen receptors initiates adaptive immune responses. Two papers in this issue of Immunity demonstrate that CARMA-1, a CARD carrying member of the MAGUK family proteins, is essential for lymphocyte activation. CARMA-1 functions by coupling antigen receptor signals to NF-kappaB induction and JNK activation.

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