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Review
. 2003 Jul;71(7):3673-81.
doi: 10.1128/IAI.71.7.3673-3681.2003.

Interleukin-10 and inhibition of innate immunity to Yersiniae: roles of Yops and LcrV (V antigen)

Robert R Brubaker  1
Affiliations
Review

Interleukin-10 and inhibition of innate immunity to Yersiniae: roles of Yops and LcrV (V antigen)

Robert R Brubaker. Infect Immun. 2003 Jul.
No abstract available

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Figures

FIG. 1.
FIG. 1.
Expression of the proinflammatory cytokines IFN-γ (○) and TNF-α (•) in C57BL/6 mouse spleen following intravenous challenge with 106 pCD− cells of Y. pestis KIM10 (A), 102 pCD+ cells of Y. pestis KIM10 (B), 102 pCD+ cells of Y. pestis KIM10 after the cells were primed with 20 μg of IFN-γ and 20 ng of TNF-α (C), and 102 pCD+ cells of Y. pestis KIM10 by passive immunization on postinfection day 1 with 100 μg of polyclonal rabbit anti-LcrV (D). All untreated mice challenged with pCD+ yersiniae died by postinfection day 6 (B), whereas the remainder survived. This figure is redrawn from the work of Nakajima and Brubaker (67) and Nakajima et al. (68).
FIG. 2.
FIG. 2.
Characteristic histopathological changes in liver caused by Y. pestis KIM10 on postinfection day 3 (hematoxylin and eosin stain). (A) Control mouse infected with pCD+ yersiniae showing multiple necrotic focal lesions without an inflammatory cell response (magnification, ×140); (B) control mouse infected with pCD− yersiniae exhibiting granuloma formation (magnification, ×280); (C) mouse actively immunized with PAV and then infected with pCD+ yersiniae showing protective granulomatous lesions (magnification, ×140); (D) mouse passively immunized with polyclonal rabbit anti-PAV and infected with pCD+ yersiniae showing pregranulomatous lesions prompting infiltration of inflammatory (mononuclear) cells (magnification, ×70). This figure was reprinted from the work of Nakijima et al. (68).
See this image and copyright information in PMC

References

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