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Comment
. 2003 Jun;11(6):1420-1.
doi: 10.1016/s1097-2765(03)00233-8.

Emi1 proteolysis: how SCF(beta-Trcp1) helps to activate the anaphase-promoting complex

Jan-Michael Peters  1
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Comment

Emi1 proteolysis: how SCF(beta-Trcp1) helps to activate the anaphase-promoting complex

Jan-Michael Peters. Mol Cell. 2003 Jun.
Free article

Abstract

Emi1 inhibits the anaphase-promoting complex (APC) during S and G2 phase. Two papers by Guardavaccaro et al. and Margottin-Goguet et al. in the June issue of Developmental Cell now show that Emi1 degradation in early mitosis is mediated by beta-Trcp1, an adaptor protein that recruits proteins to the SCF ubiquitin ligase.

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