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. 2003 Jul;47(7):2330-3.
doi: 10.1128/AAC.47.7.2330-2333.2003.

Sfh-I, a subclass B2 metallo-beta-lactamase from a Serratia fonticola environmental isolate

Maria José Saavedra  1 , Luísa Peixe, João Carlos Sousa, Isabel Henriques, Artur Alves, António Correia
Affiliations

Sfh-I, a subclass B2 metallo-beta-lactamase from a Serratia fonticola environmental isolate

Maria José Saavedra et al. Antimicrob Agents Chemother. 2003 Jul.

Abstract

An environmental isolate of Serratia fonticola resistant to carbapenems was shown to contain a genetic determinant encoding a metallo-beta-lactamase of the subclass B2. The Sfh-I enzyme exhibits some divergence from the previously characterized enzymes of this subclass. This is the first example of a naturally occurring metallo-beta-lactamase in Enterobacteriaceae.

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Figures

FIG. 1.
FIG. 1.
Alignment of the amino acid sequences of MBLs included in subclass B2. Residues conserved in the three enzymes are indicated by asterisks; dots indicate functionally homologous residues. The BBL numbering scheme is used for residues conserved in MBLs. Amino acids presumptively involved in binding to zinc are indicated by the letter z.
See this image and copyright information in PMC

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