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Review
. 2003 Jul;58(7):543-52.
doi: 10.1034/j.1398-9995.2003.00239.x.

IVIG--mechanisms of action

H U Simon  1 , P J Späth
Affiliations
Review

IVIG--mechanisms of action

H U Simon et al. Allergy. 2003 Jul.

Abstract

Intravenous immunoglobulin (IVIG) preparations are fractionated from a plasma pool of several thousand donors. IVIG contain immune antibodies and physiologic autoantibodies. Immune antibodies reflect the immunologic experience of the donor population. This fraction of IVIG preparations is useful for replacement therapy and passive immunisation. Natural autoantibodies are able to react with the immune system of the recipient of IVIG and are suggested to help to correct immune deregulation. Immunomodulatory and anti-inflammatory properties are based on multiple mechanisms of action which are described. These mechanisms are effective concomitantly and synergistically at every occasion of use of IVIG in inflammatory and autoimmune disorders.

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Comment in

  • IVIG effects on autoantibody elimination.
    Hansen RJ, Balthasar JP. Hansen RJ, et al. Allergy. 2004 Oct;59(10):1124; author reply 1124. doi: 10.1111/j.1398-9995.2004.00479_1.x. Allergy. 2004. PMID: 15355473 No abstract available.

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