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. 2003 Jul 4;17(10):1570-2.
doi: 10.1097/00002030-200307040-00022.

Selection of resistance mutations in pregnant women receiving zidovudine and lamivudine to prevent HIV perinatal transmission

Marina Giuliano  1 , Lucia Palmisano, Clementina M Galluzzo, Roberta Amici, Elena Germinario, Pius Okong, Praxedes Kituuka, Francis Mmirro, Michele Magoni, Stefano Vella
Affiliations

Selection of resistance mutations in pregnant women receiving zidovudine and lamivudine to prevent HIV perinatal transmission

Marina Giuliano et al. AIDS. .

Abstract

Two zidovudine/lamivudine regimens for the prevention of HIV perinatal transmission were studied for the selection of resistance mutations. The M184V mutation was detected one week after delivery in six out of fifty women (12%) who received the regimen prepartum, intrapartum and postpartum, and was no longer present 3 months later. No nucleoside reverse transcriptase inhibitor resistance-associated mutations were detected in 50 women who received zidovudine/lamivudine intrapartum and postpartum only. No association with the risk of perinatal transmission was found.

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