Discovery of a potent substance P antagonist: recognition of the key molecular determinant
- PMID: 1282570
- DOI: 10.1021/jm00104a018
Discovery of a potent substance P antagonist: recognition of the key molecular determinant
Similar articles
-
Potent and highly selective neurokinin antagonists.J Med Chem. 1990 Jul;33(7):1848-51. doi: 10.1021/jm00169a003. J Med Chem. 1990. PMID: 1694545 No abstract available.
-
Pharmacological properties of a potent and selective nonpeptide substance P antagonist.Proc Natl Acad Sci U S A. 1991 Nov 15;88(22):10208-12. doi: 10.1073/pnas.88.22.10208. Proc Natl Acad Sci U S A. 1991. PMID: 1719549 Free PMC article.
-
Selectivity and specificity of new, non-peptide, quinuclidine antagonists of substance P.Biochem Biophys Res Commun. 1991 Apr 30;176(2):894-901. doi: 10.1016/s0006-291x(05)80270-0. Biochem Biophys Res Commun. 1991. PMID: 1709018
-
Pharmacological and biochemical evidence for multiple types of tachykinin NK2 receptors.Ann N Y Acad Sci. 1991;632:112-5. doi: 10.1111/j.1749-6632.1991.tb33099.x. Ann N Y Acad Sci. 1991. PMID: 1719859 Review. No abstract available.
-
Receptors and antagonists for substance P and related peptides.Pharmacol Rev. 1994 Dec;46(4):551-99. Pharmacol Rev. 1994. PMID: 7534932 Review. No abstract available.
Cited by
-
Design of novel neurokinin 1 receptor antagonists based on conformationally constrained aromatic amino acids and discovery of a potent chimeric opioid agonist-neurokinin 1 receptor antagonist.J Med Chem. 2011 Apr 14;54(7):2467-76. doi: 10.1021/jm1016285. Epub 2011 Mar 17. J Med Chem. 2011. PMID: 21413804 Free PMC article.
-
Sulfinimine-derived 2,3-diamino esters in the asymmetric synthesis of piperidine (2S,3S)-(+)-CP-99,994.Tetrahedron Lett. 2007 Oct 29;48(44):7838-7840. doi: 10.1016/j.tetlet.2007.08.132. Tetrahedron Lett. 2007. PMID: 18974820 Free PMC article.
-
Three-Step Telescoped Synthesis of Monosubstituted Vicinal Diamines from Aldehydes.ACS Omega. 2019 Jan 29;4(1):2261-2267. doi: 10.1021/acsomega.8b03030. eCollection 2019 Jan 31. ACS Omega. 2019. PMID: 31459468 Free PMC article.
-
Differences in the effects of NK1-receptor antagonists, (+/-)-CP 96,345 and CP 99,994, on agonist-induced responses in guinea-pig trachea.Br J Pharmacol. 1994 May;112(1):176-8. doi: 10.1111/j.1476-5381.1994.tb13048.x. Br J Pharmacol. 1994. PMID: 7518303 Free PMC article.
-
Ethyl 2,6-bis-(4-chloro-phen-yl)-4-(4-fluoro-anilino)-1-(4-fluoro-phen-yl)-1,2,5,6-tetra-hydro-pyridine-3-carboxyl-ate.Acta Crystallogr Sect E Struct Rep Online. 2013 Mar 9;69(Pt 4):o506-7. doi: 10.1107/S1600536813006090. Print 2013 Apr 1. Acta Crystallogr Sect E Struct Rep Online. 2013. PMID: 23634054 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Other Literature Sources
Chemical Information