The ins and outs of fatty acids on the pancreatic beta cell

Affiliations

Review

Vincent Poitout. Trends Endocrinol Metab. 2003 Jul.

. 2003 Jul;14(5):201-3.

doi: 10.1016/s1043-2760(03)00086-9.

¹ Pacific Northwest Research Institute and Department of Medicine, University of Washington, Seattle, WA, USA. vpoitout@pnri.org

No abstract available

Comment on

The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids.
Briscoe CP, Tadayyon M, Andrews JL, Benson WG, Chambers JK, Eilert MM, Ellis C, Elshourbagy NA, Goetz AS, Minnick DT, Murdock PR, Sauls HR Jr, Shabon U, Spinage LD, Strum JC, Szekeres PG, Tan KB, Way JM, Ignar DM, Wilson S, Muir AI. Briscoe CP, et al. J Biol Chem. 2003 Mar 28;278(13):11303-11. doi: 10.1074/jbc.M211495200. Epub 2002 Dec 19. J Biol Chem. 2003. PMID: 12496284
A human cell surface receptor activated by free fatty acids and thiazolidinedione drugs.
Kotarsky K, Nilsson NE, Flodgren E, Owman C, Olde B. Kotarsky K, et al. Biochem Biophys Res Commun. 2003 Feb 7;301(2):406-10. doi: 10.1016/s0006-291x(02)03064-4. Biochem Biophys Res Commun. 2003. PMID: 12565875
Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40.
Itoh Y, Kawamata Y, Harada M, Kobayashi M, Fujii R, Fukusumi S, Ogi K, Hosoya M, Tanaka Y, Uejima H, Tanaka H, Maruyama M, Satoh R, Okubo S, Kizawa H, Komatsu H, Matsumura F, Noguchi Y, Shinohara T, Hinuma S, Fujisawa Y, Fujino M. Itoh Y, et al. Nature. 2003 Mar 13;422(6928):173-6. doi: 10.1038/nature01478. Epub 2003 Feb 23. Nature. 2003. PMID: 12629551