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. 2003 Jul;22(5):465-7.
doi: 10.1097/00003226-200307000-00013.

Inhibition of corneal neovascularization by genetic ablation of CCR2

Balamurali K Ambati  1 , Antonia M Joussen, William A Kuziel, Anthony P Adamis, Jayakrishna Ambati
Affiliations

Inhibition of corneal neovascularization by genetic ablation of CCR2

Balamurali K Ambati et al. Cornea. 2003 Jul.

Abstract

Purpose: To determine if genetic ablation of the chemokine receptor CCR2 (involved in leukocyte and endothelial chemotaxis) inhibits the development of corneal neovascularization.

Methods: Wild-type C57BL/6J mice, as well as species-specific counterparts with targeted homozygous disruption of the CCR2, underwent chemical and mechanical denudation of corneal and limbal epithelium. Corneas were harvested 2 weeks after injury. Neovascularization was quantified by CD31 immunostaining.

Results: The mean percentages of neovascularized corneal area in control mice and CCR2-deficient mice 2 weeks after denudation were 58.3% and 38.8% (P = 0.047), respectively.

Conclusions: Development of corneal neovascularization is inhibited in CCR2-deficient mice.

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