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Review
. 2003 Jun;20(3):304-17.
doi: 10.1039/b008338k.

Mutagenesis approaches to deduce structure-function relationships in terpene synthases

Michael J R Segura  1 , Beth E Jackson, Seiichi P T Matsuda
Affiliations
Review

Mutagenesis approaches to deduce structure-function relationships in terpene synthases

Michael J R Segura et al. Nat Prod Rep. 2003 Jun.

Abstract

This review highlights mutagenesis studies of terpene synthases, specifically sesquiterpene synthases and oxidosqualene cyclases. Mutagenesis studies of these enzymes have provided mechanistic insights, structure-function relationships for specific enzymatic residues, novel terpene structures and enzymes with novel activities. The literature through 2002 is reviewed and 113 references cited.

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