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Review
. 2003 Jun;13(3):284-99.
doi: 10.1016/s0959-440x(03)00081-2.

Recognition of the DNA minor groove by pyrrole-imidazole polyamides

Peter B Dervan  1 , Benjamin S Edelson
Affiliations
Review

Recognition of the DNA minor groove by pyrrole-imidazole polyamides

Peter B Dervan et al. Curr Opin Struct Biol. 2003 Jun.

Abstract

Many diseases, such as cancer, are related to aberrant gene expression. Regulating transcription by chemical methods could be important in human medicine. Minor groove-binding polyamides offer one chemical approach to DNA recognition.

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