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. 2003 Aug;28(8):1151-8.
doi: 10.1023/a:1024264025401.

Subcellular distribution of Homer 1b/c in relation to endoplasmic reticulum and plasma membrane proteins in Purkinje neurons

Dorianna Sandonà  1 , Alessandra Scolari, Katsuiko Mikoshiba, Pompeo Volpe
Affiliations

Subcellular distribution of Homer 1b/c in relation to endoplasmic reticulum and plasma membrane proteins in Purkinje neurons

Dorianna Sandonà et al. Neurochem Res. 2003 Aug.

Abstract

The subcellular distribution of endoplasmic reticulum proteins (IP3R1 and RYR), plasma membrane (PM) proteins (mGluR1 and PMCA Ca(2+)-pump), and scaffolding proteins, such as Homer 1b/c, was assessed by laser scanning confocal microscopy of rat cerebellum parasagittal sections. There appeared to be two classes of Ca2+ stores, nonjunctional Ca2+ stores and junctional Ca2+ stores, possibly referable to central cisternae/tubules and sub-PM cisternae, respectively, in soma, dendrites, and dendritic spines. Only some IP3R1s appeared to be part of multimeric, junctional Ca2+ signaling networks, whose composition is shown to include PMCA, mGluR1, Homer 1b/c and, not always, RYR1.

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