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Case Reports
. 2003 Jul;17(4):459-60.
doi: 10.1046/j.1468-3083.2003.00774.x.

Onycholysis and subungual haemorrhages secondary to systemic chemotherapy (paclitaxel)

E Ghetti  1 , B M Piraccini, A Tosti
Affiliations
Case Reports

Onycholysis and subungual haemorrhages secondary to systemic chemotherapy (paclitaxel)

E Ghetti et al. J Eur Acad Dermatol Venereol. 2003 Jul.

Abstract

Paclitaxel is a chemotherapic agent of the taxane family used in treatment of malignant solid tumory. We report here the case of a 40-year old woman referred to our clinic for nail changes involving all 20 digits and developed after 5 months of paclitaxel intake, due to a breast carcinoma. Clinical examination revealed red-brown discoloration of the nails associated with hematomas and onycholysis. The nail changes were very painful and the patient complained of discharge of bad-smelling yellow brown opaque fluid from underneath the nail plate. Hemorrhagic onycholysis and subungual abscesses are a possible side effect of taxane treatment that should be early recognized to prevent serious complications.

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Comment in

  • Drugs and nails.
    Uyttendaele H, Geyer A, Scher RK. Uyttendaele H, et al. J Eur Acad Dermatol Venereol. 2004 Mar;18(2):124-5. doi: 10.1111/j.1468-3083.2004.00775.x. J Eur Acad Dermatol Venereol. 2004. PMID: 15009285 No abstract available.

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