Review
doi: 10.1038/nrc1121.
Molecular mechanisms of glioma invasiveness: the role of proteases
Affiliations
- PMID: 12835669
- DOI: 10.1038/nrc1121
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Review
Molecular mechanisms of glioma invasiveness: the role of proteases
Nat Rev Cancer.
2003 Jul.
Abstract
The invasive nature of brain-tumour cells makes an important contribution to the ineffectiveness of current treatment modalities, as the remaining tumour cells inevitably infiltrate the surrounding normal brain tissue, which leads to tumour recurrence. Such local invasion remains an important cause of mortality and underscores the need to understand in more detail the mechanisms of tumour invasiveness. Several proteases influence the malignant characteristics of gliomas--could their inhibition prove to be a useful therapeutic strategy?
Comment in
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Aspects on the survival of patients with glioblastoma and the origin and histology of oligodendrogliomas.Nat Rev Cancer. 2003 Jul;3(7):doi:10.1038/nrc1121-c1. doi: 10.1038/nrc1121-c1. Nat Rev Cancer. 2003. PMID: 19006840 No abstract available.
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