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. 2001:(1):145-6.
doi: 10.1093/nass/1.1.145.

Inhibition of ICAM-1 gene expression by antisense 2',4'-BNA oligonucleotides

S Obika  1 , R Hemamayi, T Masuda, T Sugimoto, S Nakagawa, T Mayumi, T Imanishi
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Inhibition of ICAM-1 gene expression by antisense 2',4'-BNA oligonucleotides

S Obika et al. Nucleic Acids Res Suppl. 2001.

Abstract

We have previously reported that 2'-O,4'-C-methylene bridged nucleic acid (2',4'-BNA) had unprecedented binding affinity towards its complementary RNA. We reported herein that the antisense 2',4'-BNA oligonucleotides showed potent inhibitory effect on gene expression of Intercellular Adhesion Molecule-1 (ICAM-1) in living cells. The contribution of RNase H to this antisense effect and adequate stability of 2',4'-BNA oligonucleotides to enzymatic degradation were also demonstrated.

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