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. 1992 Dec;6(12):771-6.
doi: 10.1002/rcm.1290061212.

Matrix-assisted laser desorption/ionization mass spectrometry of nucleic acids with wavelengths in the ultraviolet and infrared

E Nordhoff  1 , A Ingendoh, R Cramer, A Overberg, B Stahl, M Karas, F Hillenkamp, P F Crain
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Matrix-assisted laser desorption/ionization mass spectrometry of nucleic acids with wavelengths in the ultraviolet and infrared

E Nordhoff et al. Rapid Commun Mass Spectrom. 1992 Dec.

Abstract

A number of different matrices have been tested and compared for ultraviolet and infrared (UV and IR) matrix-assisted laser desorption/ionization (MALDI) of oligodeoxyribonucleotides and mixtures thereof, as well as ribonucleic acids (tRNA from yeast and rRNA from E. coli). A new technique for removing alkali cations from nucleic acid samples during sample preparation on the sample support is demonstrated. The amount of oligonucleotide sample consumed during a typical measurement in IR-MALDI-MS was determined.

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