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. 1975 Dec 18;19(2):99-107.
doi: 10.1007/BF02563995.

Chondrocyte metabolism as affected by vitamin A

N S Vasan, J W Lash

Chondrocyte metabolism as affected by vitamin A

N S Vasan et al. Calcif Tissue Res. .

Abstract

Chondrocytes from 13-day-old embryonic chick sterna were cultured for 6 days in the presence of vitamin A (10 I.U./ml). Vitamin A treated chondrocytes became flattened and stellate within the first 24 hours of culture. After 6 days of culture, the treated cells contained 59% less DNA than the untreated controls. Sulfated glycosaminoglycan synthesis was inhibited 84%, and a greater percentage of GAG was secreted into the medium (90%) than in control cultures (78%). Vitamin A inhibited cell proliferation, and to varying degrees, RNA and protein synthesis, and these effects are dose dependent.

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