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. 1999;19(2):112-4.
doi: 10.1007/BF02886889.

Myosin-induced autoimmune myocarditis in BALB/C mice

Z Wang  1 , Y Liao, J Dong, S Li, J Wang, Y Tu
Affiliations

Myosin-induced autoimmune myocarditis in BALB/C mice

Z Wang et al. J Tongji Med Univ. 1999.

Abstract

Experimental mice were immunized with cardiac myosin and complete Freund's adjuvant (CFA) on days 0, 7 and 30 and control mice were immunized with CFA. Sera and myocardium samples were harvested on days 15, 21 and 120 after the first immunization. Pathological findings demonstrated that there were necrosis and inflammatory infiltration in acute stage and fibrosis mainly in chronic stage of experimental group. Anti-myosin antibodies were also found in sera of experimental mice, but not in control group. Our study showed that cardiac myosin served as an autoantigen to provoke autoimmunity and lead to the transformation of VMC into DCM.

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References

    1. Mol Cell Biochem. 1993 Feb 17;119(1-2):67-71 - PubMed
    1. J Immunol. 1987 Dec 1;139(11):3630-6 - PubMed
    1. Clin Immunol Immunopathol. 1993 Aug;68(2):129-34 - PubMed
    1. Circ Res. 1994 Aug;75(2):278-84 - PubMed
    1. Proc Natl Acad Sci U S A. 1992 Feb 15;89(4):1320-4 - PubMed