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. 2003 May;247(1-2):139-45.
doi: 10.1023/a:1024175325850.

The influence of lipoic acid on adriamycin-induced hyperlipidemic nephrotoxicity in rats

Kumaravel Palanichamy Malarkodi  1 , Andithangal Venkatesan Balachandar, Palaninathan Varlakshmi
Affiliations

The influence of lipoic acid on adriamycin-induced hyperlipidemic nephrotoxicity in rats

Kumaravel Palanichamy Malarkodi et al. Mol Cell Biochem. 2003 May.

Abstract

Adriamycin widely used in the treatment of neoplastic conditions is nephrotoxic. In the present study the protective effect of lipoic acid was investigated in adriamycin-induced nephrotoxicity in adult male albino Wistar rats. Adriamycin-induced nephrotoxicity was characterized by hyperlipidemia, proteinuria, and hypoproteinemia, by decreased activities of the enzymes N-acetyl-beta-D-glucosaminidase and cathepsin D, by increased lipid peroxidation and decreases in serum catalase and glutathione activities, and by increased urinary and serum urea, creatinine and urinary glycosaminoglycans. Pretreatment with lipoic acid restored the changes, indicating that lipoic acid is renoprotective in adriamycin nephrotoxicity.

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