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Editorial
. 2003 Jun;3(6):513-4.
doi: 10.1016/s1535-6108(03)00143-0.

Matrix reloaded to circulation hits the tumor target

Sara A Wickström, Jorma Keski-Oja, Kari Alitalo
Free article
Editorial

Matrix reloaded to circulation hits the tumor target

Sara A Wickström et al. Cancer Cell. 2003 Jun.
Free article

Abstract

Proteolytic fragments of various components of the extracellular matrix exhibit antiangiogenic activity via interaction with endothelial cell surface integrins. Kalluri and coworkers (this issue of Cancer Cell) use gene-targeted mice to show a physiological role for a carboxy-terminal fragment of collagen IV in the regulation of tumor angiogenesis.

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