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Review
. 2003 Apr:24 Suppl A:S10-5.
doi: 10.1053/plac.2002.0931.

Soluble HLA-G1 at the materno-foetal interface--a review

P Le Bouteiller  1 , F Legrand-Abravanel, C Solier
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Review

Soluble HLA-G1 at the materno-foetal interface--a review

P Le Bouteiller et al. Placenta. 2003 Apr.

Abstract

HLA-G differs from the other MHC class I genes. This includes a unique promoter region, a restricted constitutive tissular distribution, the translation of different membrane-bound and soluble isoforms, a shortened cytoplasmic tail and a minimal polymorphim. Soluble HLA-G1 is an immunosuppressive molecule inducing apoptosis of activated CD8(+) T cells and down-modulating CD4(+) T cell proliferation. Soluble HLA-G1 may also contribute to the control of implantation.

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