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. 1992 Sep;1(6):407-10.
doi: 10.1093/hmg/1.6.407.

Characterization of the human HOX 7 cDNA and identification of polymorphic markers

B J Padanilam  1 , H S Stadler, K A Mills, L B McLeod, M Solursh, B Lee, F Ramirez, K H Buetow, J C Murray
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Characterization of the human HOX 7 cDNA and identification of polymorphic markers

B J Padanilam et al. Hum Mol Genet. 1992 Sep.

Abstract

cDNA clones for a human HOX 7 gene obtained with homologous clones of Drosophila were used in human gene mapping studies. The human cDNA clone was isolated from a library constructed from human embryonic craniofacial material. The sequence of the cDNA demonstrates significant homology with mouse HOX 7. A search for RFLPs identified MboII and BstEII variants. A CA dinucleotide repeat with 5 alleles was also identified and allowed placement of HOX 7 into a defined linkage map. Evidence for linkage disequilibrium was found with markers tested. These results place the human HOX 7 gene in a defined position on 4p.

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