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Case Reports
. 2003 Aug;19(7-8):471-6.
doi: 10.1007/s00381-003-0781-6. Epub 2003 Jul 4.

Agenesis of corpus callosum: prenatal diagnosis and prognosis

Marie-Laure Moutard  1 , Virginie Kieffer, Josué Feingold, François Kieffer, Fanny Lewin, Catherine Adamsbaum, Antoinette Gélot, Jaume Campistol I Plana, Patrick van Bogaert, Monique André, Gérard Ponsot
Affiliations
Case Reports

Agenesis of corpus callosum: prenatal diagnosis and prognosis

Marie-Laure Moutard et al. Childs Nerv Syst. 2003 Aug.

Abstract

Introduction: Agenesis of corpus callosum (ACC) is commonly diagnosed prenatally. When isolated, it appears to carry a good prognosis but studies are often retrospective and follow-up short. We report a prospective study of 17 children (11 boys, 6 girls) with prenatally diagnosed isolated ACC.

Methods: Neuropsychological evaluation was performed each year and results at the ages of 2, 4, and 6 years were compared.

Results: Febrile seizures occurred in 3 patients. Median intellectual quotient (IQ) was within the normal range (80-109) and nonrelated to partial or complete ACC, sex, or febrile seizures. Lower median IQ was significantly related to low cultural status. With age, the number of children with IQ in the lower range (80-89) increased and slowness, attentional troubles, and instability appeared.

Conclusion: This study demonstrates that if outcome of isolated ACC is favorable, a long follow-up is necessary: with age, IQ in the lower range and behavioral troubles are linked to difficulties in school.

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References

    1. Ann N Y Acad Sci. 1989;573:360-8 - PubMed
    1. Ann Neurol. 1994 Aug;36(2):229-33 - PubMed
    1. J Radiol. 1997 Jul;78(7):499-505 - PubMed
    1. Prenat Diagn. 1995 Apr;15(4):301-12 - PubMed
    1. Arch Neurol. 1994 May;51(5):494-6 - PubMed

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