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Review
. 2003 Jun:991:107-10.
doi: 10.1111/j.1749-6632.2003.tb07468.x.

Parkinson's disease and related alpha-synucleinopathies are brain amyloidoses

John Q Trojanowski  1 , Virginia M-Y Lee
Affiliations
Review

Parkinson's disease and related alpha-synucleinopathies are brain amyloidoses

John Q Trojanowski et al. Ann N Y Acad Sci. 2003 Jun.

Abstract

A paradigm shift in understanding Parkinson's disease (PD) and related disorders is emerging from studies showing that alpha-synuclein (AS) gene mutations cause familial PD; AS is abnormally nitrated, phosphorylated, and ubiquitinated; AS forms neuronal and glial inclusions; AS fibrillizes in vitro; and AS transgenic animals develop neurodegeneration with AS amyloid inclusions. Thus, PD and related synucleinopathies are brain amyloidoses that may share similar mechanisms and targets for drug discovery.

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