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. 2003 Jul 7;198(1):1-4.
doi: 10.1084/jem.20030732.

Dangerous liaisons between a microbe and the prion protein

Adriano Aguzzi  1 , Wolf-Dietrich Hardt
Affiliations

Dangerous liaisons between a microbe and the prion protein

Adriano Aguzzi et al. J Exp Med. .
No abstract available

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Figures

Figure 1.
Figure 1.
Macrophage manipulation by B. abortus: A role for the Hsp60–PrPC interaction. B. abortus transports Hsp60 via the VirB type IV system onto its surface. Upon encounter with a macrophage, Hsp60 binds to PrPC, which is embedded in lipid rafts on the macrophage surface. This is thought to modulate phagocytosis (swimming internalization), mediate macropinosome formation, inhibit lysosome fusion, and steer the macropinosome to the formation of the replicative phagosome. Other, hitherto unknown effector proteins traveling via the VirB system are also involved (see text; based on the findings by Watarai et al. [reference 1]).
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References

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