doi: 10.1212/01.wnl.0000070782.27949.f7.
Chlamydia pneumoniae in children with MS: frequency and quantity of intrathecal antibodies
Affiliations
- PMID: 12847174
- DOI: 10.1212/01.wnl.0000070782.27949.f7
Item in Clipboard
Chlamydia pneumoniae in children with MS: frequency and quantity of intrathecal antibodies
Neurology.
.
Abstract
The authors investigated the frequency and quantity of intrathecal antibody synthesis against Chlamydia pneumoniae and the presence of C pneumoniae antigen in 25 children with MS. C pneumoniae genome was present in two children. In seven children an intrathecal synthesis of C pneumoniae antibodies was detected, representing only a small part of the total intrathecal immunoglobulin G, suggesting that this intrathecal synthesis is part of a polyspecific, oligoclonal immune response.
Similar articles
-
Chlamydia pneumoniae-specific intrathecal oligoclonal antibody response is predominantly detected in a subset of multiple sclerosis patients with progressive forms.J Neurovirol. 2009 Sep;15(5-6):425-33. doi: 10.3109/13550280903475580. J Neurovirol. 2009. PMID: 20053141
-
Intrathecal antibody production against Chlamydia pneumoniae in multiple sclerosis is part of a polyspecific immune response.Brain. 2001 Jul;124(Pt 7):1325-35. doi: 10.1093/brain/124.7.1325. Brain. 2001. PMID: 11408328
-
Chlamydia pneumoniae and multiple sclerosis: no significant association.Trends Microbiol. 2001 Apr;9(4):152-4. doi: 10.1016/s0966-842x(01)01985-0. Trends Microbiol. 2001. PMID: 11286864
-
[Multiple sclerosis. Chlamydia hypothesis in debate].Nervenarzt. 2001 Oct;72(10):820-3. doi: 10.1007/s001150170041. Nervenarzt. 2001. PMID: 11688186 Review. German.
-
[Chlamydia pneumoniae infection and multiple sclerosis].Neurol Neurochir Pol. 2002 May-Jun;36(3):489-92. Neurol Neurochir Pol. 2002. PMID: 12185805 Review. Polish.
Cited by
-
Low intrathecal antibody production despite high seroprevalence of Epstein-Barr virus in multiple sclerosis: a review of the literature.J Neurol. 2018 Feb;265(2):239-252. doi: 10.1007/s00415-017-8656-z. Epub 2017 Nov 2. J Neurol. 2018. PMID: 29098417 Review.
-
Parvovirus B19 and mumps virus antibodies are major constituents of the intrathecal immune response in European patients with MS and increase the diagnostic sensitivity and discriminatory power of the MRZ reaction.J Neurol. 2021 Oct;268(10):3758-3765. doi: 10.1007/s00415-021-10471-3. Epub 2021 Mar 26. J Neurol. 2021. PMID: 33770235 Free PMC article.
-
Chlamydia pneumoniae-specific intrathecal oligoclonal antibody response is predominantly detected in a subset of multiple sclerosis patients with progressive forms.J Neurovirol. 2009 Sep;15(5-6):425-33. doi: 10.3109/13550280903475580. J Neurovirol. 2009. PMID: 20053141
-
Neuroimmunology: Immunoglobulins and the Intrathecal Polyspecific Immune Response in Acute, Subacute and Chronic Neurological Diseases.EJIFCC. 2004 Aug 31;15(3):82-85. eCollection 2004 Aug. EJIFCC. 2004. PMID: 29988944 Free PMC article. No abstract available.
-
Multiple Sclerosis and Clostridium perfringens Epsilon Toxin: Is There a Relationship?Biomedicines. 2024 Jun 23;12(7):1392. doi: 10.3390/biomedicines12071392. Biomedicines. 2024. PMID: 39061966 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
