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Review
. 2003 Apr;38(4):465-8.
doi: 10.1007/s11745-003-1085-x.

Pathophysiologic role of redox status in blood platelet activation. Influence of docosahexaenoic acid

M Lagarde  1 , C Calzada, E Véricel
Affiliations
Review

Pathophysiologic role of redox status in blood platelet activation. Influence of docosahexaenoic acid

M Lagarde et al. Lipids. 2003 Apr.

Abstract

Decrease of platelet glutathione peroxidase activity results in increased life span of lipid hydroperoxides, especially the 12-lipoxygenase product of arachidonic acid, 12-HpETE. Phospholipase A2 activity is subsequently enhanced with the release of arachidonic acid, which results in higher thromboxane formation and platelet function. Docosahexaenoic acid may either potentiate platelet lipid peroxidation or lower it when used at high or low concentrations, respectively. In the case of slowing down lipid peroxidation, docosahexaenoic acid was specifically incorporated in plasmalogen ethanolamine phospholipids. This could have a relevant pathophysiologic role in atherothrombosis.

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References

    1. Biochim Biophys Acta. 1994 May 25;1226(2):219-24 - PubMed
    1. Prostaglandins. 1992 Jan;43(1):75-85 - PubMed
    1. Clin Biochem. 1994 Aug;27(4):293-8 - PubMed
    1. J Biol Chem. 1993 Dec 15;268(35):26796-804 - PubMed
    1. Biochem J. 1992 Jan 15;281 ( Pt 2):309-16 - PubMed

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