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Comparative Study
. 2003 Jul;56(1):135-8.
doi: 10.1046/j.1365-2125.2003.01821.x.

Comparability of whole-blood and plasma clozapine and norclozapine concentrations

R J Flanagan, B Yusufi, T R E Barnes
Comparative Study

Comparability of whole-blood and plasma clozapine and norclozapine concentrations

R J Flanagan et al. Br J Clin Pharmacol. 2003 Jul.
No abstract available

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Figures

Figure 1
Figure 1
Plots of whole-blood and plasma clozapine and norclozapine concentrations in patient samples (n = 48;formula image data points omitted in the calculation of the regression equations).
See this image and copyright information in PMC

References

    1. Cooper TB. Clozapine plasma level monitoring: current status. Psychiatr Q. 1996;67:297–311. - PubMed
    1. Miller DD. The clinical use of clozapine plasma concentrations in the management of treatment-refractory schizophrenia. Ann Clin Psychiatr. 1996;8:99–109. - PubMed
    1. Flanagan RJ, Amin A, Seinen W. Effect of post-mortem changes on peripheral and central whole blood and tissue clozapine and norclozapine concentrations in the domestic pig (Sus scrofa) Forensic Sci Int. 2003;132:9–17. - PubMed
    1. Schaber G, Stevens I, Gaertner HJ, Dietz K, Breyer-Pfaff U. Pharmacokinetics of clozapine and its metabolites in psychiatric patients: plasma protein binding and renal clearance. Br J Clin Pharmacol. 1998;46:453–459. - PMC - PubMed
    1. Guitton C, Kinowski JM, Aznar R, Bressolle F. Determination of clozapine and its major metabolites in human plasma and red blood cells by high-performance liquid chromatography with ultraviolet absorbance detection. J Chromatogr B. 1997;690:211–222. - PubMed