Review
doi: 10.1016/s0959-4388(03)00063-1.
Is synaptotagmin the calcium sensor?
Affiliations
- PMID: 12850216
- DOI: 10.1016/s0959-4388(03)00063-1
Item in Clipboard
Review
Is synaptotagmin the calcium sensor?
Curr Opin Neurobiol.
2003 Jun.
Abstract
After much debate, recent progress indicates that the synaptic vesicle protein synaptotagmin I probably functions as the calcium sensor for synchronous neurotransmitter release. Following calcium influx into presynaptic terminals, synaptotagmin I rapidly triggers the fusion of synaptic vesicles with the plasma membrane and underlies the fourth-order calcium cooperativity of release. Biochemical and genetic studies suggest that lipid and SNARE interactions underlie synaptotagmin's ability to mediate the incredible speed of vesicle fusion that is the hallmark of fast synaptic transmission.
Similar articles
-
Allosteric stabilization of calcium and phosphoinositide dual binding engages several synaptotagmins in fast exocytosis.Elife. 2022 Aug 5;11:e74810. doi: 10.7554/eLife.74810. Elife. 2022. PMID: 35929728 Free PMC article.
-
Synaptotagmin I functions as a calcium sensor to synchronize neurotransmitter release.Neuron. 2002 Dec 5;36(5):897-908. doi: 10.1016/s0896-6273(02)01065-6. Neuron. 2002. PMID: 12467593
-
synaptotagmin mutants reveal essential functions for the C2B domain in Ca2+-triggered fusion and recycling of synaptic vesicles in vivo.J Neurosci. 2001 Mar 1;21(5):1421-33. doi: 10.1523/JNEUROSCI.21-05-01421.2001. J Neurosci. 2001. PMID: 11222632 Free PMC article.
-
p65-Synaptotagmin: a docking-fusion protein in synaptic vesicle exocytosis?Neuroscience. 1993 May;54(2):323-8. doi: 10.1016/0306-4522(93)90255-e. Neuroscience. 1993. PMID: 8336827 Review. No abstract available.
-
The synaptotagmins: calcium sensors for vesicular trafficking.Neuroscientist. 2004 Dec;10(6):566-74. doi: 10.1177/1073858404268770. Neuroscientist. 2004. PMID: 15534041 Review.
Cited by
-
Asymmetric accumulation of hippocampal 7S SNARE complexes occurs regardless of kindling paradigm.Epilepsy Res. 2007 Mar;73(3):266-74. doi: 10.1016/j.eplepsyres.2006.11.003. Epub 2006 Dec 14. Epilepsy Res. 2007. PMID: 17174072 Free PMC article.
-
Crystallographic identification of Ca2+ and Sr2+ coordination sites in synaptotagmin I C2B domain.Protein Sci. 2004 Oct;13(10):2665-72. doi: 10.1110/ps.04832604. Epub 2004 Aug 31. Protein Sci. 2004. PMID: 15340165 Free PMC article.
-
Characterization of developmental and molecular factors underlying release heterogeneity at Drosophila synapses.Elife. 2018 Jul 10;7:e38268. doi: 10.7554/eLife.38268. Elife. 2018. PMID: 29989549 Free PMC article.
-
Unexpected Ca2+-binding properties of synaptotagmin 9.Proc Natl Acad Sci U S A. 2004 Feb 24;101(8):2554-9. doi: 10.1073/pnas.0308477100. Proc Natl Acad Sci U S A. 2004. PMID: 14983047 Free PMC article.
-
Different effects on fast exocytosis induced by synaptotagmin 1 and 2 isoforms and abundance but not by phosphorylation.J Neurosci. 2006 Jan 11;26(2):632-43. doi: 10.1523/JNEUROSCI.2589-05.2006. J Neurosci. 2006. PMID: 16407561 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Molecular Biology Databases
