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. 2003 Jul 25;979(1-2):225-9.
doi: 10.1016/s0006-8993(03)02942-1.

Adenosine A(2A) antagonism increases striatal glutamate outflow in the quinolinic acid rat model of Huntington's disease

Marco Gianfriddo  1 , Claudia Corsi, Alessia Melani, Antonella Pèzzola, Rosaria Reggio, Patrizia Popoli, Felicita Pedata
Affiliations

Adenosine A(2A) antagonism increases striatal glutamate outflow in the quinolinic acid rat model of Huntington's disease

Marco Gianfriddo et al. Brain Res. .

Abstract

In the quinolinic acid (QA)-rat model of Huntington's disease (HD), 15 days after QA injection, striatal glutamate, measured by in vivo microdialysis, was unchanged while a significant decrease in adenosine occurred. The decrease in adenosine may depend on QA-induced striatal cell loss. Probe perfusion of the adenosine A(2A) receptor antagonist SCH 58261 significantly increased striatal glutamate outflow, suggesting a potential detrimental effect of A(2A) antagonism at later stages of the neurodegenerative process induced by QA.

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