doi: 10.1111/j.1749-6632.2003.tb03157.x.
Exploring the stereostructural requirements of peptide ligands for the melanocortin receptors
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- PMID: 12851293
- DOI: 10.1111/j.1749-6632.2003.tb03157.x
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Exploring the stereostructural requirements of peptide ligands for the melanocortin receptors
Ann N Y Acad Sci.
2003 Jun.
Abstract
The melanotropin peptides alpha-MSH, gamma-MSH, and beta-MSH are believed to be the natural ligands for the four melanocortin receptors, MC1R, MC3R, MC4R, and MC5R. However, these peptides generally have low selectivity for these receptors. We report on some approaches to the development of selective agonists and antagonists peptide ligands for these receptors.
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