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. 2003 Jun:994:12-20.
doi: 10.1111/j.1749-6632.2003.tb03157.x.

Exploring the stereostructural requirements of peptide ligands for the melanocortin receptors

Victor J Hruby  1 , Minying Cai, Paolo Grieco, Guoxia Han, Malcolm Kavarana, Dev Trivedi
Affiliations

Exploring the stereostructural requirements of peptide ligands for the melanocortin receptors

Victor J Hruby et al. Ann N Y Acad Sci. 2003 Jun.

Abstract

The melanotropin peptides alpha-MSH, gamma-MSH, and beta-MSH are believed to be the natural ligands for the four melanocortin receptors, MC1R, MC3R, MC4R, and MC5R. However, these peptides generally have low selectivity for these receptors. We report on some approaches to the development of selective agonists and antagonists peptide ligands for these receptors.

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