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Review
. 2004 Feb;447(5):566-70.
doi: 10.1007/s00424-003-1130-z. Epub 2003 Jul 8.

The sodium bile salt cotransport family SLC10

Bruno Hagenbuch  1 , Paul Dawson
Affiliations
Free article
Review

The sodium bile salt cotransport family SLC10

Bruno Hagenbuch et al. Pflugers Arch. 2004 Feb.
Free article

Abstract

The SLC10 family of sodium/bile salt cotransporters contains over 50 members in animal, plant and bacterial species. In man, two well-characterized members and three orphan transporters are known. The Na(+)/taurocholate cotransporting polypeptide (NTCP; SLC10A1) and the apical sodium-dependent bile salt transporter (ASBT; SLC10A2) are critical components of the enterohepatic circulation of bile salts. NTCP and ASBT are cotransporters that mediate sodium-dependent, electrogenic uptake of mainly bile salts into hepatocytes (NTCP), biliary epithelial cells, ileal enterocytes and renal proximal tubular cells (ASBT).

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