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. 2003;158(1-2):121-30; discussion 130-1.

[Is the prion abnormality going to involve immunology?]

[Article in French]
A Bussard
  • PMID: 12852098

[Is the prion abnormality going to involve immunology?]

[Article in French]
A Bussard. Bull Mem Acad R Med Belg. 2003.

Abstract

The behaviour of prion type proteins, be they in mammals (Pr P) or in yeast (URE 3) suggests a non Mendelian heredity based on conformational changes in these proteins. This seems to be an anomaly in regard to molecular Biology (M.B.) which rules information transfer exclusively from DNA to protein with the use of a numeric code. This anomaly may affect M.B. in the future, but also may influence our views in Immunology. For the time being, clonal selection is the only accepted theory to explain the generation of diversity in antibodies; is it full proof?

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