Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2003 Jul;97(7):825-9.
doi: 10.1016/s0954-6111(03)00038-6.

Association between hyperhomocysteinemia and primary pulmonary hypertension

Alejandro C Arroliga  1 , Sunder Sandur, Donald W Jacobsen, Sanjiv Tewari, Masroor Mustafa, Edward J Mascha, Killian Robinson
Affiliations
Free article

Association between hyperhomocysteinemia and primary pulmonary hypertension

Alejandro C Arroliga et al. Respir Med. 2003 Jul.
Free article

Abstract

Study objective: This case-control study was conducted to test the hypothesis that fasting homocysteine levels are higher in PPH patients than in healthy controls.

Design: Levels of plasma total homocysteine, serum folate, vitamin B-12, and serum creatinine in 18 consecutive patients with PPH were compared with data from 36 age- and sex-matched controls.

Results: Eight of the 18 patients (44.4%) and three of the 36 controls (8.3%) had elevated plasma total homocysteine (tHcy) levels (> or = 15 mol/l, odds ratio 8.8; 95% CI: 2.0-39.6; P = 0.005). There was an inverse correlation between tHcy levels and creatinine clearance in patients with PPH (P = 0.036).

Conclusion: PPH patients are significantly more likely to have hyperhomocysteinemia, and higher mean plasma total homocysteine levels than in controls. Plasma total homocysteine may be an important factor in the pathogenesis of PPH.

PubMed Disclaimer

LinkOut - more resources