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. 2003 May;49(5):308-18.
doi: 10.1034/j.1600-0897.2003.00038.x.

Pro-inflammatory maternal cytokine profile in preterm delivery

M Makhseed  1 , R Raghupathy, S El-Shazly, F Azizieh, J A Al-Harmi, M M K Al-Azemi
Affiliations

Pro-inflammatory maternal cytokine profile in preterm delivery

M Makhseed et al. Am J Reprod Immunol. 2003 May.

Abstract

Problem: The objective of this study was to determine the levels of cytokines produced by maternal peripheral blood mononuclear cells (PBMC) upon stimulation with a mitogen, with autologous placental cells and with a trophoblast antigen extract.

Method of study: Peripheral blood mononuclear cells from 54 women with a history of successful pregnancy and 30 women undergoing preterm delivery (PTD) were stimulated with the mitogen and antigens, and the cytokine levels in mitogen-stimulated culture supernatants assessed.

Results: Significantly higher levels of the type 1 cytokines, interferon (IFN)-gamma and interleukin (IL)-2, were produced by the PTD group than by the normal pregnancy group, which on the contrary showed significantly greater production of the type 2 cytokines, IL-4, IL-5 and IL-10. A comparison of the ratios of type 2 to type 1 cytokines is indicative of a type 1 cytokine bias in PTD.

Conclusions: These data are suggestive of a maternal type 1 cytokine bias in PTD.

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