Are there differences in risk factor profiles and frequency of CT/MRI-based infarcts among African American stroke patients with and without hypertension? A report from the African American Antiplatelet Stroke Prevention Study (AAASPS)
- PMID: 12856908
- PMCID: PMC2594536
Are there differences in risk factor profiles and frequency of CT/MRI-based infarcts among African American stroke patients with and without hypertension? A report from the African American Antiplatelet Stroke Prevention Study (AAASPS)
Abstract
BACKGROUND; African Americans (AAs) have a high risk of stroke and a high prevalence of cardiovascular risk factors. Little is known about stroke risk profiles among non-hypertensive AAs.
Methods: African American Antiplatelet Stroke Prevention Study (AAASPS) enrollees with a history of hypertension (htn) were compared to those without htn for history of traditional cardiovascular risk factors and number and distribution of CT/MRI infarcts. Estimated odds ratios are presented describing the association between selected risk factors and htn status. The estimated odds ratios and 95% confidence intervals (CI) were obtained using multivariate logistic regression.
Results: The database for this analysis included 1012 patients with htn and 74 patients without htn. When compared to those with htn, those without htn were more commonly men (59% vs. 46%; p = 0.030), current cigarette smokers (55% vs. 37%; p = 0.001), were younger (median age: 59 years vs. 62 years; p = 0.064), had higher education (11.7 +/- 2.9 vs. 11.1 +/- 3.1; p = 0.024), had a higher number of acute strokes of unknown cause (23% vs. 13%; p=0.060), and less commonly had a history of diabetes (25% vs. 41%; p = 0.007). Those without htn had a lower mean number of old infarcts on MRI (0.94 +/- 1.40 vs. 1.45 +/- 1.60; p = 0.045), and a higher number of mean recent infarcts on CT (1.30 +/- 1.15 vs. 0.93 +/- 1.01; p = 0.031). Multivariate analysis to predict those without htn showed that these patients were more likely to be current cigarette smokers (OR = 2.89; CI = 1.60,5.49) and have higher education (OR = 1.08, CI = 0.996,1.17), and were less likely to have old CT/MRI-based infarcts (OR = 0.46; CI = 0.26,0.76).
Conclusions: AAs without htn may have a different cardiovascular risk factor profile and CT/MRI profile than AAs with htn. This baseline profile among AAs without htn may predict lower stroke recurrence rates in this ongoing trial.
Similar articles
-
Association of region of residence and immigrant status with hypertension, renal failure, cardiovascular disease, and stroke, among African-American participants in the third National Health and Nutrition Examination Survey (NHANES III).Ethn Dis. 2003 Summer;13(3):316-23. Ethn Dis. 2003. PMID: 12894955
-
Stroke risk factor profiles in African American women: an interim report from the African-American Antiplatelet Stroke Prevention Study.Stroke. 2002 Apr;33(4):913-9. doi: 10.1161/hs0402.105337. Stroke. 2002. PMID: 11935036 Free PMC article.
-
A comparison of stroke risk factors in patients enrolled in stroke prevention trials.J Natl Med Assoc. 2001 Mar;93(3):79-86. J Natl Med Assoc. 2001. PMID: 12656439 Free PMC article.
-
Improving outcomes in the post-myocardial infarction setting.J Clin Hypertens (Greenwich). 2004 Apr;6(4 Suppl 1):34-41. doi: 10.1111/j.1524-6175.2004.03566.x. J Clin Hypertens (Greenwich). 2004. PMID: 15073465 Free PMC article. Review.
-
Cardiovascular Risk Factors in Patients with Congenital Hemophilia: A Focus on Hypertension.Diagnostics (Basel). 2022 Nov 24;12(12):2937. doi: 10.3390/diagnostics12122937. Diagnostics (Basel). 2022. PMID: 36552943 Free PMC article. Review.
Cited by
-
Stroke in Black Americans.Curr Cardiol Rep. 2005 Jan;7(1):29-33. doi: 10.1007/s11886-005-0007-5. Curr Cardiol Rep. 2005. PMID: 15610644 Review.
-
Quantifying links between stroke and risk factors: a study on individual health risk appraisal of stroke in a community of Chongqing.Neurol Sci. 2011 Apr;32(2):211-9. doi: 10.1007/s10072-010-0333-2. Epub 2010 Jun 10. Neurol Sci. 2011. PMID: 20535515
References
Publication types
MeSH terms
Grants and funding
LinkOut - more resources
Full Text Sources
Medical