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Review
. 2003 Jul;16(3):430-50.
doi: 10.1128/CMR.16.3.430-450.2003.

Versatility of aminoglycosides and prospects for their future

Sergei B Vakulenko  1 , Shahriar Mobashery
Affiliations
Review

Versatility of aminoglycosides and prospects for their future

Sergei B Vakulenko et al. Clin Microbiol Rev. 2003 Jul.

Abstract

Aminoglycoside antibiotics have had a major impact on our ability to treat bacterial infections for the past half century. Whereas the interest in these versatile antibiotics continues to be high, their clinical utility has been compromised by widespread instances of resistance. The multitude of mechanisms of resistance is disconcerting but also illuminates how nature can manifest resistance when bacteria are confronted by antibiotics. This article reviews the most recent knowledge about the mechanisms of aminoglycoside action and the mechanisms of resistance to these antibiotics.

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Figures

FIG. 1.
FIG. 1.
Sites of modification by aminoglycoside-modifying enzymes.
FIG. 2.
FIG. 2.
Phosphorylation of kanamycin A by APH(3′)s.
FIG. 3.
FIG. 3.
Acetylation of kanamycin A by AAC(6′)s.
FIG. 4.
FIG. 4.
Adenylation of kanamycin A by ANT(2").
FIG. 5.
FIG. 5.
Mechanism-based inhibition of APH(3′)s.
FIG. 6.
FIG. 6.
Cyclic process of phosphorylation and release of inorganic phosphate for derivative 5 of kanamycin A.
See this image and copyright information in PMC

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