Osteopontin: a bridge between bone and the immune system

doi:10.1172/JCI19190

Review

. 2003 Jul;112(2):147-9.

doi: 10.1172/JCI19190.

Osteopontin: a bridge between bone and the immune system

Ellen M Gravallese¹

Affiliations

Affiliation

¹ Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, Room 241, 4 Blackfan Circle, Boston, Massachusetts 02115, USA. egravall@bidmc.harvard.edu

PMID: 12865402
PMCID: PMC164297
DOI: 10.1172/JCI19190

Review

Osteopontin: a bridge between bone and the immune system

Ellen M Gravallese. J Clin Invest. 2003 Jul.

. 2003 Jul;112(2):147-9.

doi: 10.1172/JCI19190.

Author

Ellen M Gravallese¹

Affiliation

¹ Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, Room 241, 4 Blackfan Circle, Boston, Massachusetts 02115, USA. egravall@bidmc.harvard.edu

PMID: 12865402
PMCID: PMC164297
DOI: 10.1172/JCI19190

Erratum in

J Clin Invest. 2003 Aug;112(4):627

Abstract

The molecular mechanisms underlying the putative role of osteopontin in the chronic inflammatory disease rheumatoid arthritis are unclear. A study in a murine model of arthritis now demonstrates that a specific antibody directed against the exposed osteopontin epitope SLAYGLR is capable of preventing inflammatory cell infiltration in arthritic joints.

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Essential role of the cryptic epitope SLAYGLR within osteopontin in a murine model of rheumatoid arthritis.
Yamamoto N, Sakai F, Kon S, Morimoto J, Kimura C, Yamazaki H, Okazaki I, Seki N, Fujii T, Uede T. Yamamoto N, et al. J Clin Invest. 2003 Jul;112(2):181-8. doi: 10.1172/JCI17778. J Clin Invest. 2003. PMID: 12865407 Free PMC article.

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References

1. Kong YY, et al. OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. Nature. 1999;397:315–323. - PubMed
1. Simonet WS, et al. Osteoprotegerin: a novel secreted protein involved in the regulation of bone density. Cell. 1997;89:309–319. - PubMed
1. Pettit, A.R., and Gravallese, E.M. 2003. Osteoprotegerin. In Targeted therapies in rheumatology. P.E. Lipsky and J.S. Smolen, editors. Martin Dunitz. London, United Kingdom/New York, New York, USA. 359–377.
1. Yamamoto N, et al. Essential role of the cryptic epitope SLAYGLR within osteopontin in a murine model of rheumatoid arthritis. J. Clin. Invest. 2003;112:181–188. doi:10.1172/JCI200317778. - PMC - PubMed
1. Denhardt DT, Noda M. Osteopontin expression and function: role in bone remodeling. J. Cell. Biochem. Suppl.>. 1998;30/31:92–102. - PubMed

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[1] Kong YY, et al. OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. Nature. 1999;397:315–323. - PubMed

[2] Kong YY, et al. OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. Nature. 1999;397:315–323. - PubMed

[3] Simonet WS, et al. Osteoprotegerin: a novel secreted protein involved in the regulation of bone density. Cell. 1997;89:309–319. - PubMed

[4] Simonet WS, et al. Osteoprotegerin: a novel secreted protein involved in the regulation of bone density. Cell. 1997;89:309–319. - PubMed

[5] Pettit, A.R., and Gravallese, E.M. 2003. Osteoprotegerin. In Targeted therapies in rheumatology. P.E. Lipsky and J.S. Smolen, editors. Martin Dunitz. London, United Kingdom/New York, New York, USA. 359–377.

[6] Pettit, A.R., and Gravallese, E.M. 2003. Osteoprotegerin. In Targeted therapies in rheumatology. P.E. Lipsky and J.S. Smolen, editors. Martin Dunitz. London, United Kingdom/New York, New York, USA. 359–377.

[7] Yamamoto N, et al. Essential role of the cryptic epitope SLAYGLR within osteopontin in a murine model of rheumatoid arthritis. J. Clin. Invest. 2003;112:181–188. doi:10.1172/JCI200317778. - PMC - PubMed

[8] Yamamoto N, et al. Essential role of the cryptic epitope SLAYGLR within osteopontin in a murine model of rheumatoid arthritis. J. Clin. Invest. 2003;112:181–188. doi:10.1172/JCI200317778. - PMC - PubMed

[9] Denhardt DT, Noda M. Osteopontin expression and function: role in bone remodeling. J. Cell. Biochem. Suppl.>. 1998;30/31:92–102. - PubMed

[10] Denhardt DT, Noda M. Osteopontin expression and function: role in bone remodeling. J. Cell. Biochem. Suppl.>. 1998;30/31:92–102. - PubMed

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Osteopontin: a bridge between bone and the immune system

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Osteopontin: a bridge between bone and the immune system

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