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. 2003 Jun;48(5):345-7.
doi: 10.1177/070674370304800512.

Diabetes mellitus and impaired glucose tolerance in patients with schizophrenia

Mythily Subramaniam  1 , Siow-Ann Chong, Elaine Pek
Affiliations

Diabetes mellitus and impaired glucose tolerance in patients with schizophrenia

Mythily Subramaniam et al. Can J Psychiatry. 2003 Jun.

Abstract

Objectives: This study aimed to establish the prevalence of diabetes mellitus (DM) and impaired glucose tolerance in patients with schizophrenia and to elucidate some of the factors associated with hyperglycemia.

Methods: We studied a sample of 194 patients with schizophrenia. We determined fasting blood glucose and insulin levels at the start of the testing period; patients were given an oral glucose tolerance test after an overnight fast.

Results: The overall prevalence of diabetes and impaired glucose tolerance in these patients was 16.0% and 30.9%, respectively. These rates were higher than those reported in the general population. Patients with disordered glucose homeostasis were significantly older (P = 0.005, Kruskal-Wallis test). There was no significant effect of sex or ethnicity on diabetes.

Conclusions: Our findings suggest that patients with schizophrenia are more vulnerable to developing DM. We caution clinicians to be mindful of the increased risk and to be vigilant for such a development.

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