Review
Mechanisms contributing to antidepressant zinc actions
Affiliations
- PMID: 12866713
Item in Clipboard
Review
Mechanisms contributing to antidepressant zinc actions
Pol J Pharmacol.
2002 Nov-Dec.
Free article
Abstract
Zinc is a trace element, which is an important modulator of mammalian nervous and immune systems. Its deficiency is related to human depression. Our recent data indicate involvement of zinc in the mechanism of antidepressant treatment. Moreover, zinc exhibits antidepressant-like effects in animal models of depression in rodents. Since zinc also enhances antidepressant effect in laboratory animals, its potential therapeutic value in human depression is under evaluation. This article reviews the alterations in central and peripheral zinc homeostasis in relation to pathophysiology and treatment of depression.
Similar articles
-
[The role of zinc in the pathogenesis and treatment of affective disorders].Psychiatr Pol. 2005 Sep-Oct;39(5):899-909. Psychiatr Pol. 2005. PMID: 16358590 Review. Polish.
-
[The role of copper and magnesium in the pathogenesis and treatment of affective disorders].Psychiatr Pol. 2005 Sep-Oct;39(5):911-20. Psychiatr Pol. 2005. PMID: 16358591 Review. Polish.
-
Alterations in zinc homeostasis in depression and antidepressant therapy.Pol J Pharmacol. 1998 Jan-Feb;50(1):1-4. Pol J Pharmacol. 1998. PMID: 9662732 Review.
-
Lower serum zinc in major depression is a sensitive marker of treatment resistance and of the immune/inflammatory response in that illness.Biol Psychiatry. 1997 Sep 1;42(5):349-58. doi: 10.1016/S0006-3223(96)00365-4. Biol Psychiatry. 1997. PMID: 9276075 Clinical Trial.
-
[Therapeutic monitoring of antidepressant drugs].Ann Biol Clin (Paris). 1999 Jul-Aug;57(4):463-8. Ann Biol Clin (Paris). 1999. PMID: 10432370 French.
Cited by
-
Zinc and fatty acids in depression.Neurochem Res. 2010 Sep;35(9):1376-83. doi: 10.1007/s11064-010-0194-3. Epub 2010 Jun 4. Neurochem Res. 2010. PMID: 20524151
-
Modulation of antidepressant-like activity of magnesium by serotonergic system.J Neural Transm (Vienna). 2007 Sep;114(9):1129-34. doi: 10.1007/s00702-007-0714-8. Epub 2007 Apr 20. J Neural Transm (Vienna). 2007. PMID: 17447000
-
Lower Serum Zinc and Higher CRP Strongly Predict Prenatal Depression and Physio-somatic Symptoms, Which All Together Predict Postnatal Depressive Symptoms.Mol Neurobiol. 2017 Mar;54(2):1500-1512. doi: 10.1007/s12035-016-9741-5. Epub 2016 Feb 5. Mol Neurobiol. 2017. PMID: 26846364
-
Development of novel Zn2+ loaded nanoparticles designed for cell-type targeted drug release in CNS neurons: in vitro evidences.PLoS One. 2011 Mar 23;6(3):e17851. doi: 10.1371/journal.pone.0017851. PLoS One. 2011. PMID: 21448455 Free PMC article.
-
Brain-Delivery of Zinc-Ions as Potential Treatment for Neurological Diseases: Mini Review.Drug Deliv Lett. 2011 Sep;1(1):13-23. doi: 10.2174/2210303111101010013. Drug Deliv Lett. 2011. PMID: 22102982 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
