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. 2002 Nov-Dec;54(6):707-10.

Anxiolytic- and antidepressant-like effects of group III metabotropic glutamate agonist (1S,3R,4S)-1-aminocyclopentane-1,3,4-tricarboxylic acid (ACPT-I) in rats

Ewa Tatarczyńska  1 , Agnieszka Pałucha, Bernadeta Szewczyk, Ewa Chojnacka-Wójcik, Joanna Wierońska, Andrzej Pilc
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  • PMID: 12866729
Free article

Anxiolytic- and antidepressant-like effects of group III metabotropic glutamate agonist (1S,3R,4S)-1-aminocyclopentane-1,3,4-tricarboxylic acid (ACPT-I) in rats

Ewa Tatarczyńska et al. Pol J Pharmacol. 2002 Nov-Dec.
Free article

Abstract

We examined the anxiolytic-like activity of (1S,3R,4S)-1-aminocyclopentane-1,3,4-tricarboxylic acid (ACPT-I) using the Vogel conflict drinking test, while antidepressant-like effects of this compound were evaluated using Porsolt's test. ACPT-I, a selective group III mGlu receptor agonist, produced a dose-dependent anticonflict effect after intrahippocampal injections and antidepressant-like effect in rats after intraventricular injections. These data suggest that selective group III mGlu receptor agonists may become a new class of anxiolytics and/or antidepressants.

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