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. 2003 Jul 25;68(15):5936-42.
doi: 10.1021/jo034308v.

Synthesis of isocoumarins and alpha-pyrones via electrophilic cyclization

Tuanli Yao  1 , Richard C Larock
Affiliations

Synthesis of isocoumarins and alpha-pyrones via electrophilic cyclization

Tuanli Yao et al. J Org Chem. .

Abstract

A variety of substituted isocoumarins and alpha-pyrones are readily prepared in excellent yields under very mild reaction conditions by the reaction of o-(1-alkynyl)benzoates and (Z)-2-alken-4-ynoates with ICl, I(2), PhSeCl, p-O(2)NC(6)H(4)SCl, and HI. This methodology accommodates various alkynyl esters and has been successfully extended to the synthesis of polycyclic aromatic and biaryl compounds.

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