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Review
. 1992;11(3-4):252-9.
doi: 10.1007/BF02919131.

Eosinophil IgE receptor and CD23

M Capron  1 , M J Truong, D Aldebert, V Gruart, M Suemura, G Delespesse, B Tourvieille, A Capron
Affiliations
Review

Eosinophil IgE receptor and CD23

M Capron et al. Immunol Res. 1992.

Abstract

In the present review, eosinophil Fc epsilon RII was compared to CD23, a differentiation marker of B cells. Biochemical analysis revealed that molecules of similar molecular weight were immunoprecipitated from eosinophils and B cells by an anti-CD23 monoclonal antibody (mAb) or by BB10, and anti-eosinophil Fc epsilon RII. By flow cytometry, a correlation was found between the binding of anti-CD23 mAb and myeloma IgE. However, a low expression of different epitopes of CD23 was observed in various hypereosinophilic patients. Northern blot analysis of eosinophil RNA with the cDNA probe of CD23 revealed a weak message in only 3 of the 6 patients expressing membrane CD23. The inhibition by anti-CD23 mAbs of IgE-mediated cytotoxicity and IgE binding to eosinophils clearly indicated the participation of CD23 or a related molecule in IgE-dependent eosinophil functions. However, the differential effects of anti-CD23 mAbs on eosinophils and B cells suggest major differences in the characteristics of the molecule expressed by eosinophils and by B cells.

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References

    1. J Immunol. 1986 Sep 1;137(5):1659-64 - PubMed
    1. J Immunol. 1984 Jan;132(1):462-8 - PubMed
    1. J Exp Med. 1990 Sep 1;172(3):693-700 - PubMed
    1. Immunology. 1990 Jun;70(2):251-7 - PubMed
    1. J Immunol. 1990 Apr 1;144(7):2638-46 - PubMed