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Comparative Study
. 2003 Aug 18;13(16):2651-4.
doi: 10.1016/s0960-894x(03)00551-1.

Tetrabiphenylporphyrin-based receptors for protein surfaces show sub-nanomolar affinity and enhance unfolding

Toshihiro Aya  1 , Andrew D Hamilton
Affiliations
Comparative Study

Tetrabiphenylporphyrin-based receptors for protein surfaces show sub-nanomolar affinity and enhance unfolding

Toshihiro Aya et al. Bioorg Med Chem Lett. .

Abstract

A family of tetrabiphenylporphyrin-based receptors has been synthesized. Receptor 7 showed sub-nanomolar affinity (K(d)=0.67 nM) in binding to the surface of cytochrome c. In addition, a stoichiometric amount of the receptor 7 caused a lowering in the T(m) of cytochrome c from 85 to 35 degrees C.

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